2024 college football Week 4 picks based on spreads, odds, lines, trends: Vegas expert reveals top picks

Young quarterbacks will be in the spotlight as the fourth week of college football’s schedule rolls around. Sophomore Jackson Arnold and No. 15 Oklahoma face redshirt freshman Niko Iamalewa and No. 6 Tennessee in a marquee matchup on Saturday, with the Vols listed as 7-point road favorites in Week 4 college football odds via SportsLine consensus. Redshirt freshman Arch Manning could get his first career start for top-ranked Texas, while Quinn Ewers (oblique) is uncertain to play. The Longhorns are big 44.5-point favorites against UTSA.

Freshman Dylan Raiola and No. 22 Nebraska will have a ranked matchup on Friday evening, taking on No. 24 Illinois (+7.5). Which of these Week 4 college football lines should you target? Before locking in any Week 4 college football picks on those games or others, be sure to check out the college football betting guide from veteran Vegas handicapper Bruce Marshall.

For many years, the Vegas-based Marshall was synonymous with the renowned sports betting newsletter, The Gold Sheet. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when the legendary Mort Olshan hired him and served as executive editor for several years.

A sought-after guest on numerous sports talk radio and TV shows across the country, Bruce’s vast range of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won numerous handicapping titles and is also working on several book projects.

Now, using his Take Corner technology, which evaluates all the trends and the latest college football odds, Marshall turns his attention to college football betting for Week 4 and reveals picks for each matchup. Head here to see every pick.

Top college football predictions for Week 4

One of Marshall’s recommended top college football picks for Week 4: He’s backing No. 15 Oklahoma (+7) against the spread for the Sooners’ matchup with the Vols in Norman on Saturday at 7:30 p.m. ET.

Tennessee is undoubtedly a great starter to start the season as the Vols have allowed more than 20 points in their first three games. However, this is the first true road start for Iamalewa, and it should be against a very aggressive crowd as the Sooners are playing their first SEC game.

The Vols covered just once on the road last year, while Oklahoma has covered at home in seven of its last nine. Marshall expects a competitive game and likes OU to get the full seven points, while also backing the over (57.5) as these teams are 4-2 overall so far in 2024. Here’s a look at what other challenges lie ahead.

How to make college football picks for Week 4

Marshall has evaluated every other matchup and he’s got a staggering 11-0 betting trend that you should know this week. Get betting analysis for every matchup at SportsLine.

So what kind of picks can you trust in college football, and what shocking trends do you need to know about in one of the biggest games of the week? Check out the latest college football odds below, then head over to SportsLine to see which teams to back, all from a veteran Vegas expert who’s won multiple handicapping titles, and find out.

Week 4 College Football Odds

Check out complete Week 4 college football picks, odds, predictions here

Thursday, September 19

South Alabama vs. Appalachian State (-7.5, 64.5)

Friday, September 20

Stanford vs. Syracuse (-9, 57.5)

Illinois vs. Nebraska (-8.5, 43)

San Jose State vs. Washington State (-11.5, 55.5)

Saturday, September 21

North Carolina State vs. Clemson (-20.5, 46.5)

Florida vs. Mississippi State (+6, 58.5)

Marshall at Ohio State (-39.5, 52.5)

Arkansas vs. Auburn (-3, 58)

USC vs. Michigan (+6, 46.5)

Utah vs. Oklahoma State (+2.5, 54)

Tennessee vs. Oklahoma (+7, 57.5)

Louisiana-Monroe vs. Texas (-44, 52.5)

Baylor at Colorado (-1.5, 53.5)

Kansas State vs. BYU (+7, 47.5)

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