College football odds, picks, predictions for Week 4, 2024: Proven model likes Florida State in best bets

Colorado bounced back from a tough loss at Nebraska last week with a 28-9 win over rival Colorado State, but will now look to avoid any disappointment when it hosts Baylor on Saturday night. The Buffaloes have made headlines since the start of last season, while the Bears have been flying under the radar in the Week 4 college football schedule. Colorado is a slight 1.5-point favorite in the Week 4 college football odds, making it the most interesting of the Week 4 college football spreads.

There are also four ranked vs. ranked matchups this weekend, with No. 6 Tennessee (-7) and No. 15 Oklahoma facing off on Saturday night. The Vols have scored more than 50 points in each of their first three games, while the Sooners have outscored Houston and Tulane in their first SEC game. OU started out as the favorite in the lookahead lines, but that spread has shifted dramatically in Tennessee’s favor. Before locking in any Week 4 college football picks on those games or others, be sure to check out the latest college football predictions from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Since its launch, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start this season on over/under picks. Anyone who has followed it has seen strong returns!

Now, it turns its attention to the latest college football odds and Week 4 college football betting lines based on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 4

One of the college football picks the model favors the most during Week 4: UCLA (+24.5) remains well within the spread at No. 16 LSU in Saturday’s 3:30 p.m. ET matchup. The Tigers are riding an 11-game home winning streak and are coming off a 36-33 road win at South Carolina, but they haven’t covered the spread in any of their first three games. They have failed to cover in five consecutive September contests and are 3-9 against the spread in their last 12 Week 4 games, making them a team likely to fade as a heavy favorite.

UCLA opened its campaign with a road win at Hawaii before losing to Indiana at home last week. Senior quarterback Ethan Garbers threw for 409 yards and scored a touchdown while also rushing for 68 yards, giving LSU another dual-threat quarterback to deal with. The Bruins are 4-1 in their last five games against SEC opponents, and the model has them covering the spread in over 70% of the latest simulations. Check out the rest of Week 4 college football picks here.

Another prediction: Florida State (-2.5) will finally win out and cover the spread against California at 7 p.m. ET kickoff on Saturday. Finding value is all about getting the right numbers, and Florida State’s brutal start to the season makes Saturday night a valuable contrasting spot. The Seminoles have certainly been disappointing in their first three games, but they were 17-point home favorites against Boston College just two weeks ago.

Meanwhile, Cal trailed by 12 points when playing against unranked Auburn earlier this month, so this is a big turnaround. The Golden Bears are coming off a poor performance against a San Diego State team that was playing without its starting quarterback. They committed 12 penalties for 113 yards in that contest, and it will be difficult for them to go on the road and pull off an upset with such undisciplined mistakes. SportsLine’s model has Florida State getting its first win of the season on Saturday, as the Seminoles are covering the spread in over 60% of simulations. Check out picks for every other game in Week 4 here.

How to make college football picks for Week 4

The model also has predicted who wins and who covers in every FBS matchup in Week 4, and it’s calling several underdogs to win outright. You can find every pick for every game, only at SportsLine.

So which college football picks can you make with confidence, and which underdogs win outright in Week 4? Check out the latest college football odds below, then head over to SportsLine to see which teams win and cover the spread, all from a proven computer model that has produced over $2,000 in profit since its inception, and find out.

College Football Odds for Week 4

Check out complete Week 4 college football picks, odds, predictions here

Thursday, September 19

South Alabama vs. Appalachian State (-7, 62.5)

Friday, September 20

Stanford vs. Syracuse (-8.5, 57.5)

Illinois vs. Nebraska (-8.5, 43.5)

San Jose State vs. Washington State (-11.5, 55.5)

Saturday, September 21

North Carolina State vs. Clemson (-20.5, 46.5)

Florida vs. Mississippi State (+6, 58.5)

Marshall at Ohio State (-39.5, 52.5)

Arkansas vs. Auburn (-3, 56.5)

USC at Michigan (+5.5, 44.5)

Utah vs. Oklahoma State (+2.5, 54)

Tennessee vs. Oklahoma (+7, 57.5)

Louisiana-Monroe vs. Texas (-44.5, 52.5)

Baylor at Colorado (-1.5, 51)

Kansas State vs. BYU (+6.5, 48.5)

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